Key result
Current evidence from a few small studies is insufficient to predict definite consequences of the potential negative synergistic interaction between statins and succinylcholine.
Why the study?
Does the co-administration of statins and succinylcholine cause serious muscular damage in cardiac patients undergoing anesthesia?
Does the co-administration of statins and succinylcholine cause serious muscular damage in cardiac patients undergoing anesthesia?
The potential for serious muscular damage from the interaction between statins and succinylcholine during anesthesia remains a concern with insufficient evidence to definitively guide clinical practice.
Insufficient evidence on statin-succinylcholine synergy warrants perioperative caution; leaves open the need for larger trials to quantify risks.
Statins are being extensively used in cardiac patient throughout the globe. Succinylcholine has been the mainstay of profound relaxation during induction and intubation of anesthesia for almost six decades now. The interactive properties of these drugs have been of major concern during routine anesthesiology practice in the last few years. However, no major research trial, prospective studies or meta-analysis are available, which can truly allay the fears of possible potential negative synergistic interactions between these two commonly used drugs. Whatever the evidence is available is hardly enough to support a positive outcome and the results have been drawn from observations of only few small studies. As a result, a continuous need among anesthesiologist fraternity is felt to arrive at a suitable inference, which can predict definite consequences of this synergistic interaction. The present article reviews some of the important observations of few handful studies which were carried out to observe any potential adverse interactions between succinylcholine and statins.
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Sukhminder JitSingh Bajwa (2013) conducted a review in Cardiac patients undergoing anesthesia. Statins and succinylcholine co-administration was evaluated on Potential adverse interactions (serious muscular damage). Current evidence from a few small studies is insufficient to predict definite consequences of the potential negative synergistic interaction between statins and succinylcholine.
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