RECENT investigations have established some of the physiologic reactions of the thyrotropic hormone and have raised other questions as to its role in health and disease. Studies made with radioactive iodine indicate that the thyrotropic hormone will promote the release and uptake of thyroid iodine. Leblond and co-workers (1, 2, 3) have demonstrated that the thyroid-stimulating hormone (TSH) will promote the collection of radioiodine by the thyroid, and conversely, hypophysectomized rats will show less accumulation of iodine by the thyroid than intact control rats. The first effect of TSH on iodine metabolism in the thyroid would appear to be the purging of the thyroid of its stored iodine (4). This loss of iodine would appear to precede the hypertrophy of the thyroid cell which occurs when TSH is administered (5). De Robertis and his associates (6–11) have suggested that TSH activates to some extent a proteolytic enzyme present in the thyroid colloid.
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Sonenberg et al. (1952) studied this question.
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