ISOLATION AND STRUCTURAL ELUCIDATION OF FLAVONOLIGNAN DERIVATIVE FROM Melochia corchorifolia: EVALUATION OF THEIR BIOLOGICAL, ANTICANCER ACTIVITY AND MOLECULAR DOCKING STUDIES

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Ethanolic extract of leaves Melochia corchorifolia subjected to silica gel column chromatography and the compounds obtained are analyzed for antioxidant activity.Among the compounds collected and tested, compound four showed a maximum antioxidant potential of 90.74±0.65%by DPPH activity.Flavonolignan, a flavonoid derivative compound, was isolated and structurally characterized using various spectral analyses.The antimicrobial activity of the compound showed maximum activity of 16mm and 20mm in 75µg/ml and 100µg/ml concentrations against the human pathogenic microorganisms.Molecular docking studies of the compound showed better binding affinity and H-bond interaction with the human breast cancer estrogen receptor (3EQM) with binding energy of about -9.91 kcal/mol.We observed that the isolated compound showed a potent anticancer effect against MCF-7 cells from the preliminary results.