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Combining infrared dual-comb spectroscopy with laser-induced nanosecond temperature-jumps enables fast tracking of peptide folding dynamics. Compared to single-wavenumber quantum cascade lasers, this method provides broader spectral information. Using a model peptide system, the study opens new perspectives for applying time-resolved IR spectroscopy to explore mechanistic details in biomolecular dynamics.
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Mattes et al. (2025) studied this question.
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