Key result
Male sex is linked to greater development of thoracic collateral circulation compared to females.
Why the study?
Is there a sex-linked difference in the development of collateral circulation of thoracic origin in patients with iliac artery occlusive disease?
Observational (n=839)
Is there a sex-linked difference in the development of collateral circulation of thoracic origin in patients with iliac artery occlusive disease?
This study identifies a significant male preponderance in the development of thoracic collateral circulation in patients with iliac artery occlusive disease.
May inform angiographic interpretation in iliac occlusion; leaves open sex-specific mechanisms and clinical relevance.
Aorto-femoral angiography carried out in 839 patients revealed that 139 males and females had uni- or bilateral occlusion of the common or external iliac arteries. Pelvic or lumbar/intercostal arteries served as collaterals in 786 patients. In the remaining 53 patients the collateral blood supply originated from the thoracic arteries. Among the 53 patients, only 7 were females. A chi 2-test revealed the difference to be significant (p less than 0.0005), indicating a sex-linked difference, a male preponderance, in the development of collateral circulation of thoracic origin.
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Conrad et al. (1986) conducted an observational in Iliac Artery Occlusive Disease (n=839). Male sex vs. Female sex was evaluated on Development of collateral circulation of thoracic origin (p=<0.0005). Male sex was associated with a significant preponderance in the development of collateral circulation of thoracic origin compared to females (p<0.0005).
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