December 4, 1987Science
Similarity of Cruzin, an Inhibitor of Trypanosoma cruzi Neuraminidase, to High-Density Lipoprotein
Key result
Cruzin and HDL both inhibit T. cruzi neuraminidase and restore epimastigote multiplication in vitro.
Why the study?
Does cruzin or high-density lipoprotein restore the multiplication rate of Trypanosoma cruzi epimastigotes in lipoprotein-depleted medium?
Population
Trypanosoma cruzi epimastigotes and purified cruzin/high-density lipoprotein
Comparison
Cruzin or high-density lipoprotein vs Medium depleted of lipoproteins
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May implicate HDL in T. cruzi survival in vitro; hypothesis-generating with no current clinical implications.
Structured PICO
Does cruzin or high-density lipoprotein restore the multiplication rate of Trypanosoma cruzi epimastigotes in lipoprotein-depleted medium?
P
Population
Trypanosoma cruzi epimastigotes and purified cruzin/high-density lipoprotein
I
Intervention
Cruzin or high-density lipoprotein
C
Comparator
Medium depleted of lipoproteins
O
Outcome
Inhibition of Trypanosoma cruzi neuraminidase and multiplication rate of Trypanosoma cruzi epimastigotessurrogate
Cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, is structurally and functionally similar to high-density lipoprotein, which may be important for the parasite's survival.
Cite This Study
Prioli et al. (1987) studied Trypanosoma cruzi. Cruzin and high-density lipoprotein vs. Medium depleted of lipoproteins was evaluated on Inhibition of Trypanosoma cruzi neuraminidase and restoration of multiplication rate. Cruzin is structurally similar to high-density lipoprotein, and both inhibit Trypanosoma cruzi neuraminidase and restore the multiplication rate of T. cruzi epimastigotes in vitro.