Key result
Higher preoperative sPAP linked to ~4% greater 30-day all-cause mortality risk per mmHg.
Why the study?
Pulmonary hypertension is associated with adverse perioperative events, but the specific relationship between preoperative echocardiographic systolic pulmonary artery pressure and perioperative outcomes in non-cardiac surgery required investigation.
Does elevated preoperative systolic pulmonary artery pressure predict perioperative mortality and morbidity in patients undergoing non-cardiac surgery?
Population
3049 patients undergoing non-cardiac surgery with preoperative TTE-estimated sPAP
Comparison
sPAP <35 mmHg vs 35-39 mmHg vs ≥ 40 mmHg
Design
Single-center retrospective study
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Elevated preoperative sPAP may refine risk stratification before non-cardiac surgery; hypothesis-generating for prospective validation and intervention trials.
Observational (n=3,049)
No
Does elevated preoperative systolic pulmonary artery pressure predict perioperative mortality and morbidity in patients undergoing non-cardiac surgery?
Odds Ratio: 1.037 (95% CI 1.016–1.058)
Absolute Event Rate: 7.3% vs 1.9%
p-value: p=0.001
Elevated preoperative systolic pulmonary artery pressure (≥40 mmHg) is an independent predictor of 30-day all-cause mortality and adverse postoperative outcomes in patients undergoing non-cardiac surgery.
A 2023 study conducted an observational in Patients undergoing non-cardiac surgery (n=3,049). Elevated systolic pulmonary artery pressure (sPAP ≥40 mmHg) vs. Normal systolic pulmonary artery pressure (sPAP <35 mmHg) was evaluated on 30-day all-cause mortality (OR 1.037, 95% CI 1.016-1.058, p=0.001). Preoperative systolic pulmonary artery pressure ≥40 mmHg was associated with increased 30-day all-cause mortality (7.3% vs 1.9% for <35 mmHg), with sPAP acting as an independent predictor of mortality (OR 1.037 per mmHg increase).
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