Key result
IV epinephrine boluses reverse acute RV failure postintubation in a patient with severe mitral stenosis.
Case Report (n=1)
No
Intravenous epinephrine can effectively reverse acute right ventricular failure and severe hypotension following induction and intubation in patients with severe mitral stenosis.
Answers are grounded in this paper and cite their sources.
May support epinephrine for acute RV failure in severe MS; single case leaves open need for prospective validation.
Mitral stenosis (MS) is prevalent in 0.02-0.2% of the population in developed countries. The pathophysiology of MS results in elevated left atrial pressures and over-time results in pulmonary hypertension (HTN) which ultimately affects the right ventricle. In addition, MS restricts the diastolic filling of the left ventricle. Therefore, during induction patients with MS are limited by their ability to increase cardiac output by increasing stroke volume. Anesthesia goals in severe MS are to avoid sudden changes in heart rate, as well as systemic and pulmonary artery pressures. We report a patient who sustained severe hypotension upon induction and intubation which was resistant to conventional medications. Intraoperative transesophageal echocardiography displayed unique right atrial and right ventricular dilatation. In addition, the leftward inter-ventricular, inter-atrial septal shift and septal bounce were noted as the characteristic findings. Intravenous epinephrine bolus was administered to achieve normo-tension and normal chamber dimensions and interventricular septal position.
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Musuku et al. (2018) conducted a case report in Mitral stenosis and acute right ventricular failure (n=1). Intravenous epinephrine bolus was evaluated on Hemodynamic stability and right ventricular function recovery. Intravenous epinephrine boluses successfully restored normotension, normal chamber dimensions, and interventricular septal position in a patient with severe mitral stenosis who developed acute right ventricular failure postintubation.
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