Key result
A dorsal/dorsomedial internal carotid artery origin (angle ≥60 degrees) was independently associated with having an ICA bulb IMT in the highest quartile (left OR 2.99; 95% CI 1.86-4.83; P<0.001).
Why the study?
Does a dorsal/dorsomedial angle of internal carotid artery origin increase the risk of early atherosclerosis at the ICA bulb in a normal population?
Population
1300 individuals from a normal population aged 40 to 70 years
Comparison
Dorsal/dorsomedial internal carotid artery origin vs Other angles of ICA origin (<60 degrees)
Design
Cross-sectional
Authors
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Supports role of ICA origin in bulb atherosclerosis; leaves open causal role and prospective validation.
Cross-Sectional (n=1,300)
Does a dorsal/dorsomedial angle of internal carotid artery origin increase the risk of early atherosclerosis at the ICA bulb in a normal population?
Odds Ratio: 2.99 (95% CI 1.86–4.83)
p-value: p=<0.001
A dorsal/dorsomedial angle of internal carotid artery origin (≥60 degrees) is independently associated with early atherosclerotic changes at the ICA bulb, suggesting local anatomic factors contribute to atherogenesis.
Sitzer et al. (2003) conducted a cross-sectional in Atherosclerosis (n=1,300). Dorsal/dorsomedial internal carotid artery origin (angle ≥60 degrees) vs. Other angles of origin was evaluated on ICA bulb IMT in the highest quartile (left side) (OR 2.99, 95% CI 1.86-4.83, p=<0.001). A dorsal/dorsomedial internal carotid artery origin (angle ≥60 degrees) was independently associated with having an ICA bulb IMT in the highest quartile (left OR 2.99; 95% CI 1.86-4.83; P<0.001).