Key result
SHBG predicts adiponectin levels after BMI adjustment, accounting for ~7% of variation.
Cross-Sectional (n=785)
In healthy adolescents, adiponectin levels are associated with SHBG and free androgen index independently of BMI, suggesting a link between adiponectin and androgen bioavailability.
SHBG-adiponectin association in healthy adolescents is hypothesis-generating; leaves open causal role of androgen bioavailability and should not change practice.
BACKGROUND/AIMS: Adiponectin is an adipose tissue-derived adipocytokine which, starting at puberty, is present in lower levels in males than in females. In adults, a relationship between adiponectin levels and sexual hormones has been suggested, but this association remains unclear in children. Our study aimed to analyze the relationship of adiponectin with dehydroepiandrosterone sulfate, testosterone, estradiol, and sex hormone-binding globulin (SHBG) in adolescents. METHODS: The population-based sample included 785 healthy 12- to 16-year-old children. Testosterone, estradiol, and dehydroepiandrosterone sulfate levels were assessed by radioimmunoassay. SHBG was measured by immunoradiometric assay. Adiponectin concentrations were measured by ELISA. RESULTS: Adiponectin levels were positively correlated with SHBG and negatively correlated with the free androgen index independently of body mass index (BMI) and fat mass. No significant correlations were observed between adiponectin and total testosterone or estradiol. Multiple linear regression analysis showed that, after adjustment for BMI, SHBG appears as the primary predictor of adiponectin levels in both sexes, accounting for 5.7% of the variation in adiponectin levels in boys and 7.5% in girls. CONCLUSION: Adiponectin is related to free androgen index and SHBG levels in adolescents after adjusting for BMI and fat mass, thus suggesting an association between adiponectin levels and androgen bioavailability that would explain the sex-based differences in adiponectin levels through life.
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Riestra et al. (2013) conducted a cross-sectional in Healthy (n=785). Sex hormone levels (SHBG, free androgen index, testosterone, estradiol, DHEAS) was evaluated on Relationship of adiponectin with sex hormone levels. Sex hormone-binding globulin (SHBG) was the primary predictor of adiponectin levels after BMI adjustment, accounting for 5.7% of variation in boys and 7.5% in girls.
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