Key result
Epidemic strains of Echovirus type 9 demonstrated definite antigenic differences compared to the prototype Hill strain and were highly neurotropic.
May necessitate revised Echovirus 9 diagnostics; leaves open clinical and epidemiologic validation in modern cohorts.
The characteristics of epidemic strains of Echovirus type 9 were compared with the prototype Hill strain. Definite antigenic differences were demonstrated; however, they are not the classical prime relationships, but correspond more closely to the variant relationships demonstrated with Echovirus type 4. The virus was highly neurotropic, and was easily recovered from specimens of CSF. African green monkey kidney cells were most sensitive for recovery of virus.
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Haynes et al. (1971) studied Echovirus 9 infection. Epidemic strains of Echovirus type 9 vs. Prototype Hill strain was evaluated on Antigenic differences and viral characteristics. Epidemic strains of Echovirus type 9 demonstrated definite antigenic differences compared to the prototype Hill strain and were highly neurotropic.
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