Key result
High-intensity interval training significantly improved peak oxygen uptake compared to moderate-intensity continuous training (MD 1.78; 95% CI 0.80-2.76) in patients with HFrEF.
Why the study?
Exercise training is an effective supplementary treatment for heart failure, but the optimal exercise regimen remains controversial.
Does high-intensity interval training improve exercise capacity, cardiac function, and quality of life compared to moderate-intensity continuous training in patients with heart failure with reduced ejection fraction?
Meta-Analysis
Does high-intensity interval training improve exercise capacity, cardiac function, and quality of life compared to moderate-intensity continuous training in patients with heart failure with reduced ejection fraction?
In patients with HFrEF, high-intensity interval training is superior to moderate-intensity continuous training for improving aerobic capacity, cardiac function, and quality of life.
HIIT may be prioritized over MICT in HFrEF to boost aerobic capacity; reinforces Level 1 meta-analytic support for exercise training.
Background: Exercise training is commonly employed as a efficacious supplementary treatment for individuals suffering from heart failure, but the optimal exercise regimen is still controversial. The objective of the review was to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the exercise capacity, cardiac function, quality of life (QoL) and heart rate among patients with heart failure with reduced ejection fraction. Methods: A systematic search was performed using the following eight databases from their inception to July 5, 2023: PubMed, Web of Science, Embase, Cochrane Library, Clinical Trials, China Knowledge Network, Wan fang Data, and the China Biology Medicine databases. The meta-analysis results were presented as mean difference (MD) and 95% confidence interval (CI). The Cochrane Risk of Bias tool was used for the included studies. The Grading of Recommendations Assessment, Development, and Evaluations was used to assess the certainty of evidence. Results: Thirteen randomized controlled trials were included in the study. The results showed that HIIT had a significant positive effect on peak oxygen uptake (MD = 1.78, 95% CI for 0.80-2.76), left ventricular ejection fraction (MD = 3.13, 95% CI for 1.25-5.02), six-minute walk test (MD = 28.13, 95% CI for 14.56-41.70), and Minnesota Living with Heart Failure Questionnaire (MD = -4.45, 95% CI for -6.25 to -2.64) compared to MICT. However, there were no statistically significant differences observed in resting heart rate and peak heart rate. Conclusions: HIIT significantly improves peak oxygen uptake, left ventricular ejection fraction, six-minute walk test, and Minnesota Living with Heart Failure Questionnaire in patients with heart failure with reduced ejection fraction. Additionally, HIIT exhibits greater effectiveness in improving peak oxygen uptake among patients with lower body mass index. Systematic Review Registration: https://www.doi.org/10.37766/inplasy2023.7.0100, identifier (INPLASY2023.7.0100).
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yang et al. (2024) conducted a meta-analysis in Heart failure with reduced ejection fraction. High-intensity interval training (HIIT) vs. Moderate-intensity continuous training (MICT) was evaluated on Peak oxygen uptake (MD 1.78, 95% CI 0.80-2.76). High-intensity interval training significantly improved peak oxygen uptake compared to moderate-intensity continuous training (MD 1.78; 95% CI 0.80-2.76) in patients with HFrEF.
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