Lithium Acetate-catalyzed Michael Reaction between Trimethylsilyl Enolate and α,β-Unsaturated Carbonyl Compound

Lithium acetate-catalyzed Michael reaction between trimethylsilyl enolates and α,β-unsaturated carbonyl compounds in DMF proceeded smoothly to afford the corresponding Michael-adducts in good to high yields. Hindered α,β-unsaturated ketones also behaved as an excellent Michael-acceptor in the above reaction at room temperature.