Aryl unplugged: Two conceptually new disconnections are equivalent to arylation of enantioenriched carbanions obtained by asymmetric deprotonation. One retrosynthesis (see scheme, above) involves N-Boc pyrrolidine (Boc=tert-butoxycarbonyl, Ar=aryl) and an organozinc intermediate, and the other (below) O-alkyl carbamates with organoboron intermediates.
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O’Brien et al. (2008) studied this question.
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