Epileptic seizures were induced electrically in rats paralyzed and ventilated with oxygen. Dissociation of brain polysomes and increase in ribosomal dimers were observed after multiple (25 or more) seizures, but were not seen after shorter treatments (up to 10 seizures). Polysomal dissociation and dimer formation occurred in vivo and were accompanied by decreased amino acid incorporation into brain proteins in cell‐free systems in vitro. These events paralleled changes in brain energy reserves rather than changes in behavior.
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Claude G. Wasterlain (1977) studied this question.
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