Impact of bilateral intraovarian platelet-rich plasma in women with poor ovarian response or primary ovarian insufficiency: a retrospective study

OBJECTIVE: To investigate the association of autologous platelet-rich plasma (PRP) treatment with functional ovarian reserve parameters and in vitro fertilization (IVF) outcomes of poor ovarian responders and women with primary ovarian insufficiency (POI) who refused oocyte donation. DESIGN: Observational, retrospective, multicentric cohort study SUBJECTS: Three hundred fifty-three women who underwent PRP treatment, including 207 poor responders and 146 diagnosed with POI. EXPOSURE: Intraovarian PRP injection. MAIN OUTCOME MEASURES: Main outcomes were antral follicular counts (AFCs) and serum antimüllerian hormone (AMH). Secondary outcomes were IVF parameters and reproductive outcomes. RESULTS: = 1.9 ± 1.7), but improvements in IVF or reproductive outcomes were not detected. CONCLUSION: Our results suggest that PRP did not induce quantitative effects on the ovaries, as oocyte and embryo yields were not increased. However, in poor responders, retrieved oocytes seemed more capable of maturing and being fertilized. For POI patients, intraovarian PRP treatment did not improve IVF or reproductive outcomes, and thus, alternatives are still required. Prospective randomized clinical trials are recommended to validate these retrospective findings and elucidate potential mechanisms for PRP-induced ovarian reactivation.