Evaluación experimental de nanopartículas como vehículos de administración controlada de fármacos: resultados preliminares in vitro

The development of nanotechnology-based drug delivery systems has revolutionized strategies for therapeutic targeting, enabling more precise and efficient pharmacological interventions. This study presents a comparative in vitro evaluation of three nanoparticle platforms—PLGA, lipid-based, and mesoporous silica nanoparticles—as vehicles for controlled drug delivery. The formulations were characterized in terms of particle size, zeta potential, drug release kinetics at physiological and acidic pH, thermal stability, and cellular uptake. PLGA nanoparticles demonstrated optimal release under acidic conditions, making them promising for tumor-targeted therapies. Lipid nanoparticles offered enhanced biocompatibility and uptake, while mesoporous silica nanoparticles stood out for their high thermal resistance and prolonged drug retention. The integration of artificial intelligence in modeling drug release patterns supported the predictive reliability of the experimental data. These findings highlight the potential of tailored nanocarrier systems in improving drug bioavailability, stability, and delivery precision, laying the groundwork for future in vivo and clinical research.