Key result
Intravenous 14C-ONO-5046·Na shows dose-dependent pharmacokinetics, rapid distribution, and near-complete excretion within 72 hours in rats.
ONO-5046Na exhibits rapid systemic distribution and primarily renal excretion in rats, with notable sex differences in the routes of elimination.
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Fujimoto et al. (1997) studied Healthy (Pharmacokinetic study). 14C-ONO-5046·Na was evaluated on Pharmacokinetic parameters (elimination half-life, AUC, distribution, excretion). After single intravenous administration to rats, 14C-ONO-5046·Na showed dose-dependent pharmacokinetics up to 1 mg/kg, rapid whole-body distribution, and near-complete excretion within 72 hours.
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