Key result
A PUFA diet in aging mice magnified the post-MI inflammatory response and delayed wound healing by increasing neutrophil infiltration (P<0.05) and proinflammatory lipid mediators.
Population
C57BL/6J mice (12-mo-old for aging groups, 3-5 mo old for young group)
Comparison
Polyunsaturated fatty acid diet feeding for 5… vs Standard lab chow-fed young mice and aging alone…
Design
Preclinical
Follow-up
up to 5 days post-MI
Authors
Loading...
Hypothesis-generating for PUFA effects on post-MI healing in aging; human studies needed before any clinical consideration.
p-value: p=<0.05
In a mouse model of myocardial infarction, the combination of aging and a PUFA-induced obesogenic diet magnifies the post-MI inflammatory response and delays wound healing.
Lopez et al. (2014) studied Myocardial infarction. Polyunsaturated fatty acid (PUFA) diet vs. Standard lab chow (LC) was evaluated on Neutrophil infiltration (p=<0.05). A PUFA diet in aging mice magnified the post-MI inflammatory response and delayed wound healing by increasing neutrophil infiltration (P<0.05) and proinflammatory lipid mediators.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: