Key result
Sodium channel β1 subunits undergo regulatory S-palmitoylation, tyrosine phosphorylation, and intramembrane proteolysis.
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Does not alter arrhythmia management; leaves open whether these modifications modulate channel function or drug response in vivo.
-palmitoylation of a VGSC β subunit, establishing precedence for this post-translational modification as a regulatory mechanism in this protein family.
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Bouza et al. (2020) studied this question. Sodium channel β1 subunits undergo S-palmitoylation, tyrosine phosphorylation, and intramembrane proteolysis, establishing precedence for these post-translational regulatory mechanisms.
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