A detailed kinetic study on pressure‐temperature inactivation of alkaline phosphatase has been performed in the pressure range 0.1 to 725 MPa at temperatures between 25 and 63 °C. Inactivation could be accurately described by a first order kinetic model, allowing D‐values to be calculated. According to the thermal death time terminology, z r ‐ and z p ‐values were calculated, expressing temperature and pressure dependence respectively. However, at high temperature, pressure dependence could not be calculated unambiguously. D‐values firstly increased with increasing pressure up to 300 MPa and then decreased with further pressure increase, showing thermal inactivation to be counteracted by low pressure. Finally, a global model describing the D‐value as a function of pressure and temperature has been formulated.
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Ludikhuyze et al. (2000) studied this question.
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