Role of autologous fat graft in the treatment of radiotherapy toxicity

According to the recent information, it was revealed that adipose tissue derived mesenchymal stem cells have ability to turn into proliferation and differentiation cells.As a result, in the treatment of many disorders such as cleft lip and cleft palate, burn scars, progressive hemifacial atrophy, myocardial infarction, spinal cord injuries, neurological deficits and many congenital or post-traumatic defects, autogene fat graft has been started to use.With successful results of clinical and experimental publications, new projects have been put together exponentially.Adipose tissue derived stem cells were reported to either reduce or prevent RT related toxicity with angiogenic, anti-apoptotic and multipotent cellular activity properties.Today, in the treatment of radiation induced toxicity, autologous fat grafting has also been started to use.However irritated tissue is counted as ischemic, either to what extent fat cells in these tissues differentiate or how they are affected are not known.Despite current use of fat graft to reduce complications, further studies examining fat graft viability under radiation therapy are needed.