Growth hormones isolated from beef, whale, monkey and human pituitaries have been investigated with respect to their ability to elicit body-weight gain in hypophy-sectomized female rats. Whale and beef hormones elicited a continuous increase of body-weight for 90 days, whereas primate somatotropins exerted this effect only for 10 days. After 10 days of injections with monkey or human hormones, animals became resistant to the effect of primate somatotropins, although no corresponding decrease in response to whale or bovine hormones was evident.
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Li et al. (1959) studied this question.