Regina G. Ziegler, Susan C. Rossi, Thomas R. Fears, H. Leon Bradlow, Herman Adlercreutz, Daniel Sepkovic, Paula Kiuru, Kristiina Wahala, Jimmie B. Vaught, Jennifer L. Donaldson, Roni T. Falk, Capri-Mara Fillmore, Pentti K. Siiteri, Robert N. Hoover, Mitchell H. Gail, Quantifying Estrogen Metabolism: An Evaluation of the Reproducibility and Validity of Enzyme Immunoassays for 2-Hydroxyestrone and 16α-Hydroxyestrone in Urine, Environmental Health Perspectives, Vol. 105, Supplement 3: Breast Cancer (Apr., 1997), pp. 607-614
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Ziegler et al. (1997) studied this question.