What question did this study set out to answer?

Investigate the chemical addition of nitrosyl chloride to steroid 5-enes and evaluate nuclear magnetic resonance spectroscopy for determining steroid stereochemistry.

June 1, 1964The Journal of Organic Chemistry

Reaction of Nitrosyl Chloride with Steroid 5-Enes.1 Nuclear Magnetic Resonance as a Stereochemical Tool in Steroids

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Authors

AHAlfred HäßnerBar-Ilan University CHClayton H. HeathcockUniversity of California, Berkeley

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Implication

Experimental chemical study reveals the addition of nitrosyl chloride to steroid 5-enes, demonstrating nuclear magnetic resonance as a stereochemical tool.

Key Points

Investigate the chemical addition of nitrosyl chloride to steroid 5-enes and evaluate nuclear magnetic resonance spectroscopy for determining steroid stereochemistry.
Treated steroid 5-ene substrates with nitrosyl chloride under controlled synthetic reaction conditions.
Analyzed the resulting adducts and stereochemical configurations using nuclear magnetic resonance spectroscopy.
Demonstrated the addition of nitrosyl chloride across the double bond of steroid 5-ene frameworks.
Established nuclear magnetic resonance spectroscopy as an effective analytical method for assigning stereochemical orientations in modified steroid structures.

Cite This Study

Häßner et al. (1964) studied this question.

synapsesocial.com/papers/6aa4026922af0bded4f43509 https://doi.org/10.1021/jo01029a019

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Implication

Experimental chemical study reveals the addition of nitrosyl chloride to steroid 5-enes, demonstrating nuclear magnetic resonance as a stereochemical tool.

Reaction of Nitrosyl Chloride with Steroid 5-Enes.1 Nuclear Magnetic Resonance as a Stereochemical Tool in Steroids

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Member takes

Implication

Key Points

Cite This Study

Reaction of Nitrosyl Chloride with Steroid 5-Enes.1 Nuclear Magnetic Resonance as a Stereochemical Tool in Steroids

Discussion

Member takes

Implication

Key Points

Cite This Study

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