Key result
Acute VTE rates rise ~50% from 1985 to 2009, driven by increased PE occurrence.
Observational (n=5,025)
Absolute Event Rate: 168% vs 112%
The incidence of clinically recognized acute VTE increased significantly from 1985 to 2009 in a Massachusetts population, driven primarily by an increase in pulmonary embolism diagnoses alongside increased non-invasive testing.
VTE incidence rose over decades, likely from increased PE detection; leaves open true trends versus diagnostic changes.
Background: Venous thromboembolism (VTE), comprising the conditions of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common acute cardiovascular event associated with increased long-term morbidity, functional disability, all-cause mortality, and high rates of recurrence. Major advances in identification, prophylaxis, and treatment over the past 3-decades have likely changed its clinical epidemiology. However, there are little published data describing contemporary, population-based, trends in VTE prevention and management. Objectives: To examine recent trends in the epidemiology of clinically recognized VTE and assess the risk of recurrence after a first acute episode of VTE. Methods: We used population-based surveillance to monitor trends in acute VTE among residents of the Worcester, Massachusetts, metropolitan statistical area (WMSA) from 1985 through 2009, including in-hospital and ambulatory settings. Results: Among 5,025 WMSA residents diagnosed with acute PE and/or lowerextremity DVT between 1985 and 2009 (mean age = 65 years), 46% were men and 95% were white. Ageand sex-adjusted annual event rates (per 100, 000) of clinically recognized acute first-time and recurrent VTE was 142 overall, increasing from 112 in 1985/86 to 168 in 2009, due primarily to increases in PE occurrence. During this period, non-invasive diagnostic VTE testing increased,
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Wei Huang (2014) conducted an observational in Venous thromboembolism (VTE) (n=5,025). Calendar year (2009) vs. Calendar year (1985/86) was evaluated on Age- and sex-adjusted annual event rates (per 100,000) of clinically recognized acute first-time and recurrent VTE. The age- and sex-adjusted annual event rate of clinically recognized acute VTE increased from 112 per 100,000 in 1985/86 to 168 per 100,000 in 2009, primarily due to increases in PE occurrence.
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