The serum levels and urinary excretion of doxycycline, a new tetracycline analogue, were studied in 10 patients with normal and 10 patients with severely impaired renal function. No statistically significant difference was noted between serum levels in two groups, but urinary excretion of the drug was significantly diminished in patients with impaired renal function. The urinary levels in the latter group, however, still surpassed the minimum inhibitory concentration of most urinary pathogens. The drug did not produce azotaemia and showed no other toxic effects.
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Ao et al. (2009) studied this question.