Nasopharyngeal carcinoma: a model cancer to understand tumor rejection

In a recent study published in Proc Natl Acad Sci USA , we demonstrated that the impaired expression of MHC-I due to elevated levels of miR-155 contributes to immune evasion in diffuse large B cell lymphoma. 1 This research builds on our previous publication, showing that the silencing of ICOSL by miR-155 overexpression, 2 combined with the newly identified role of miR-155 in regulating MHC-I, are key events in disallowing even large numbers of infiltrating cytotoxic T cells, that we call “frustrated T cells”, from eliminating the tumor cells.