Key result
A highly persistent and reward-dependent temperament is linked to the highest physiological CHD risk factors.
Why the study?
Do specific temperament profiles relate to the early development of metabolic cardiovascular syndrome in young men?
Cohort (n=190)
Do specific temperament profiles relate to the early development of metabolic cardiovascular syndrome in young men?
Specific temperament profiles, particularly those with high persistence and reward dependence and low harm avoidance, may predispose young men to the development of metabolic cardiovascular syndrome.
May aid early CHD risk stratification in young men; leaves open causal role and need for prospective trials.
Our aim in this study was to (1) identify naturally occurring temperament profiles in young adulthood by using Cloninger's temperament dimensions and (2) examine the relationship of these profiles with the coronary heart disease (CHD) risk factors of the metabolic cardiovascular syndrome (insulin resistance syndrome, IRS) measured during adolescence and young adulthood. A randomly selected sample of 190 healthy, young adult men was divided into 4 temperament groups by cluster analysis. Physiological parameters studied were serum insulin, high density lipoprotein cholesterol, triglycerides, systolic blood pressure, body-mass index, subscapular skinfold thickness, and the IRS factor. The results showed that a temperament profile characterized by a high level of persistence and reward dependence, an average level of novelty seeking, and a low level of harm avoidance was related to a high level of physiological CHD risk factors; in 3 study phases over a 6-year period, the subjects belonging to that cluster in adulthood were shown to have always belonged to the highest risk group in terms of the physiological risk factors in adolescence and young adulthood. The findings suggest that the temperament profile in question may predispose an individual to the development of the IRS and CHD.
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Keltikangas–Järvinen et al. (1999) conducted a cohort in Metabolic cardiovascular syndrome risk (n=190). Temperament profile (high persistence and reward dependence, average novelty seeking, low harm avoidance) vs. Other temperament profiles was evaluated on Physiological CHD risk factors (serum insulin, HDL cholesterol, triglycerides, systolic blood pressure, BMI, subscapular skinfold thickness, IRS factor). A temperament profile with high persistence and reward dependence, average novelty seeking, and low harm avoidance was associated with the highest level of physiological CHD risk factors over 6 years.
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