In the most recently published research article in Nature , 1 it has been demonstrated for the first time that the TET2 regulates the chromatin structure and leukaemogenesis in stem cells and leukaemia cells via MBD6 (binds 5-methycytosine residues in RNA) and NSUN2 (a RNA methylase). This important finding might pave the way for the development of highly specific novel therapeutic approaches for TET2-mutated cancers.
No takes yet. Share an insight, caveat, or question.
Dempke et al. (2025) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: