What question did this study set out to answer?

To evaluate the construct validity, factor structure, and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) in children undergoing weaning from prolonged opioid and sedative therapy.

November 18, 2011PainOpen Access

Validity and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) for monitoring iatrogenic withdrawal syndrome in pediatric patients

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To evaluate the construct validity, factor structure, and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) in children undergoing weaning from prolonged opioid and sedative therapy.
Multicenter cohort study including 126 pediatric patients (median age 1.6 years, IQR 0.6–7.7) across 21 centers who required mechanical ventilation for acute respiratory failure and received ≥5 days of opioids.
Trained staff conducted 836 daily evaluations using the 11-item, 12-point WAT-1 from the start of weaning until 72 hours after the final opioid dose.
Factor analyses confirmed that motor-related symptoms and behavioral state accounted for the greatest variance in WAT-1 scores, with scores showing no significant differences across age groups.
Children with WAT-1 scores ≥3 had significantly higher cumulative opioid exposures (40.2 vs 17.6 mg/kg, P=.004), longer pre-weaning opioid exposure (7 vs 5 days, P=.004), and longer weaning periods (10 vs 6 days, P=.008) than those with scores <3.

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Implication

Multicenter cohort study demonstrates validity of the WAT-1 scale in critically ill children, highlighting its clinical utility for monitoring opioid withdrawal.

Cite This Study

Franck et al. (2011) studied this question.

synapsesocial.com/papers/6aa41dfe04de40c43bb15719 https://doi.org/10.1016/j.pain.2011.10.003

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Implication

Multicenter cohort study demonstrates validity of the WAT-1 scale in critically ill children, highlighting its clinical utility for monitoring opioid withdrawal.

Validity and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) for monitoring iatrogenic withdrawal syndrome in pediatric patients

Key Points

Discussion

Implication

Cite This Study

Validity and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) for monitoring iatrogenic withdrawal syndrome in pediatric patients

Key Points

Discussion

Implication

Cite This Study

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