Histological changes in the uterus of rabbits after an administration of cadmium

The effects of cadmium on the uterus of rabbits were studied by light microscopy with morphometry. The experiment involved 32 animals. Cadmium was applied intraperitoneally (i.p.) to group A (1.5 mg/kg body weight), perorally (p.o.) to group B (1.0 mg/kg b.w.) for a 5‐month period, and also p.o. (1.0 mg/kg b.w.) for a 5‐month period of application followed by a 7‐month cessation of application for group C. All experimental groups were compared to a control group (K), as well as to other experimental groups. Animals were examined after the experimental period. In the uterus, the amount of endometrium was in the range of 48.42% to 50.37%, and that of myometrium of 51.58% to 49.63%. The percentage of glandular epithelium in the endometrium was significantly lower in group A in comparison with group C (P<0.05). Amount of stroma was significantly higher in the group receiving i.p., in comparison with the group receiving p.o. administration for a 5‐month period (P<0.01). From the photographed pictures edematization of uterus with desintegrations in the blood vessel wall and subsequent diapedesis were evident.