Key result
Genealogic analysis suggests the syndrome of oligophrenia, ichthyosis, and spastic diaplegia originates from one gene mutation.
Population
Patients with a clinical syndrome characterized by low-grade oligophrenia, pronounced ichthyosis, and…
Design
Case_series
Authors
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May aid recognition of this rare triad; leaves open molecular confirmation and prevalence studies.
Observational
Describes a novel clinical syndrome of oligophrenia, congenital ichthyosis, and spastic disorders originating from a single gene mutation.
Frederick A. Horner (1959) conducted an observational in Oligophrenia, congenital ichthyosis, and spastic disorders. A detailed genealogic and geographic analysis of a syndrome characterized by oligophrenia, ichthyosis, and spastic diaplegia suggested that it originates from a single gene mutation.
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