Key result
Daily 45 g Jarlsberg cheese is associated with sustained serum osteocalcin increases following initial loading.
Why the study?
Although a daily maximum effective dose of Jarlsberg cheese increased serum osteocalcin, vitamin K2, and improved lipid patterns, the daily maintenance dose remained to be estimated and verified.
Does a maintenance dose of Jarlsberg cheese maintain serum osteocalcin levels in healthy premenopausal females?
Does a maintenance dose of Jarlsberg cheese maintain serum osteocalcin levels in healthy premenopausal females?
Effect estimate: 6.6% reduction
Absolute Event Rate: 18.5% vs 19.8%
A daily maintenance dose of 45 g of Jarlsberg cheese is sufficient to maintain elevated serum osteocalcin and vitamin K2 levels in healthy premenopausal women.
45 g/day Jarlsberg may sustain osteocalcin in premenopausal women; leaves open fracture prevention or need for RCTs.
Background: Daily maximum effective dose (MED) of Jarlsberg® increased the serum osteocalcin (tOC) level, vitamin K2 and affected the lipid pattern positively. The aim of the study was to estimate and verify a daily maintenance dose. Methods: 12 healthy female volunteers (HV) were included in a de-escalation study after a six week run-in period on the daily MED of 57 g Jarlsberg® cheese. A 3-level within-patient response surface pathway (RSP) design with individual starting values was developed. Another 12 HVs were included in a new study with a six week run-in period on MED followed with six weeks on the estimated maintenance dose. All HVs were premenopausal female between 20 and 52 years of age. The main variable in the studies was the tOC level. Results: tOC, cOC and the vitamin K2 variants increases significantly (p<0.01) during the run-in period on daily MED of Jarlsberg® in both studies. The maintenance daily dose was estimated to 45 g (95% CI: 38-52 g/day) and used in the new study. The tOC level was reduced from 19.8 ng/ml (95% CI: 12.0-27.6) obtained in the run-in period to 18.5 ng/ml (95% CI: 11.7-25.3) during the maintenance part. This represents a reduction of 6.6%. The sum of vitamin K2 variants changed from 0.58 ng/ml on MED of Jarlsberg® to 0.59 ng/ml (95% CI: 0.37-0.82) during the maintenance period. Conclusions: Daily MED of Jarlsberg® cheese increases tOC, cOC and the vitamin K2 level. The maintenance Jarlsberg® dose was estimated to 45 g/day and verified as sufficient.
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Lundberg et al. (2021) studied Healthy volunteers (n=24). Jarlsberg cheese vs. 57 g/day (maximum effective dose run-in) was evaluated on Total serum osteocalcin (tOC) level (6.6% reduction). A daily maintenance dose of 45 g of Jarlsberg cheese was estimated and verified as sufficient to sustain the increased serum osteocalcin levels achieved after a 6-week run-in period on 57 g/day.
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