Answers are grounded in this paper and cite their sources.
An efficient and clean method was developed for the three components, one-pot synthesis of pyrimidinone/thione derivatives using cyclopentanone, variety of aromatic aldehydes, and urea/thiourea by using cyanuric chloride catalyzed Biginelli-type reaction. The reactions proceed under room temperature in presence of cyanuric catalyst in acetonitrile solvent. Under similar conditions, urea/thiourea exhibited similar behavior and aliphatic aldehydes showed lower reactivity than aromatic aldehydes.
No takes yet. Share an insight, caveat, or question.
Hote et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: