Key result
A short head-up tilt test protocol with a 20-minute passive phase yielded a positive response rate of 58%, which was not significantly different from the 64.7% rate observed with a 45-minute long protocol (p=0.060).
Why the study?
Vasovagal syncope is common in children and adolescents, and the study aimed to evaluate sublingual nitroglycerine-stimulated head-up tilt test protocols by comparing passive phases of 20 minutes versus 45 minutes.
Does a short HUTT protocol with a 20-minute passive phase provide comparable diagnostic yield to a long protocol with a 45-minute passive phase in children with recurrent syncope?
RCT (n=293)
Open-label
Randomly assigned
Does a short HUTT protocol with a 20-minute passive phase provide comparable diagnostic yield to a long protocol with a 45-minute passive phase in children with recurrent syncope?
A short HUTT protocol with a 20-minute passive phase provides comparable diagnostic results to a 45-minute protocol in children, offering a time-saving alternative for evaluating vasovagal syncope.
Supports shorter HUTT in pediatric syncope; leaves open confirmation via randomized trials before practice change.
Objective: Vasovagal syncope is a common clinical problem in children and adolescents, for which the head-up tilt test (HUTT) is the standard diagnostic procedure.In this study, we evaluated sublingual nitroglycerine-stimulated HUTT protocols, comparing the results with passive phases of 20 minutes versus 45 minutes.Method: A total of 293 patients aged 6 to 18 years with a history of recurrent syncope were studied.Physical examination, laboratory parameters, and echocardiographic examination were normal in all.The patients underwent standard HUTT with sublingual nitroglycerin used in the active phase.A short protocol was used for one group (n=143) with a passive phase of 20 minutes, while testing in the others (n=150) comprised a long protocol, with a passive phase of 45 minutes.Results: There were no significant differences between the two groups in terms of age, sex, and length of time between the first syncope and the tilt test.In the short protocol group, HUTT results were positive in 43(30.1%) in the passive phase, 40(28%) in the active phase, and 83(58%) overall, compared with 65(43.3%), 32(21.3%),and 97(64.7%),respectively, in the long protocol group.Among those in the long protocol group, 26 of 32 (81.5%) who had a positive response in the passive phase developed syncope within the first 20 minutes.Conclusion: The HUTT protocol with a short passive phase has the advantage of saving time while providing results comparable with the long protocol, which might be preferable in children and adolescents.Keywords: children, head-up tilt test, vasovagal syncope Giriş: Vazovagal senkop, çocuklarda ve ergenlerde hayat kalitesini bozan yaygın bir problemdir.Tanı aşamasında eğik masa testi (HUTT) standart tanı prosedürüdür.Günümüze kadar farklı protokoller kullanılmıştır.Bu çalışmamızda 20 dakika veya 45 dakika pasif faz sonrası sublingual nitrogliserin ile provakasyon uygulanan iki ayrı eğik masa testi protokolü karşılaştır ıldı.Yöntem: Tekrarlayan senkop öyküsü olan 6-18 yaşları arasında toplam 293 hasta incelendi.Fizik muayene, laboratuvar parametreleri ve ekokardiyografik incelemeleri normal olan hastalar çalışmaya dahil edildi.Grup 1'de (n =143) 20 dakikalık pasif fazlı kısa bir protokol kullanılırken, grup 2'de (n =150) 45 dakikalık pasif fazlı uzun bir protokol kullanılmıştır.Aktif Fazda tüm hastalara sublingual nitrogliserin uygulandı.Bulgular: İki grup arasında yaş, cinsiyet ve ilk senkop ile tilt testi arasında geçen süre açısından anlamlı fark yoktu.Kısa protokol grubunda, 43'ünde (% 30,1) pasif fazda, 40'ında (% 28) aktif fazda olmak üzere hastaların %58'inde test pozitif saptandı.Uzun protokol grubunda ise pasif fazda 65 (%43,3), aktif fazda 32 (%21,3) toplamda 97 (%64,7)hastada test pozitif saptandı.Uzun protokol grubunda pasif fazda senkop gelişen 32 hastadan 26'sında (% 81,5) senkop ilk 20 dakika içinde gelişti .
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Devecí et al. (2022) conducted an RCT in Vasovagal syncope (n=293). Short head-up tilt test protocol (20-minute passive phase) vs. Long head-up tilt test protocol (45-minute passive phase) was evaluated on Positive head-up tilt test response (p=0.060). A short head-up tilt test protocol with a 20-minute passive phase yielded a positive response rate of 58%, which was not significantly different from the 64.7% rate observed with a 45-minute long protocol (p=0.060).
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