Key result
Cholinesterase locus 1 phenotypes AJ, AK, and JK are linked to succinylcholine apnea vulnerability.
Individuals with AJ, AK, and JK phenotypes at cholinesterase locus 1 should be considered vulnerable to succinylcholine apnoea.
May prompt family screening for these alleles before succinylcholine; leaves open validation in larger cohorts before practice change.
A family segregating for the A, J, and K alleles at cholinesterase locus 1 is described. Several further examples of the AJ and AK phenotypes occur in this family, and one member of the family, by genetic analysis, is phenotype JK. In relation to possible succinylcholine apnoea, phenotypes AJ, AK, and JK should all be considered vulnerable.
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Evans et al. (1980) studied this question. Cholinesterase locus 1 phenotypes AJ, AK, and JK are all considered clinically vulnerable to succinylcholine apnea.
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