High‐yield chemical syntheses of phosphoramidite building blocks of the four arabinonucleosides aUrd (1), aCyd (2), aAdo (3), and aGuo (4), suitable for (3′–5′)oligoarabinonucleotide synthesis are described. The problem of 2′‐hydroxy group protection was solved by introduction of the versatile 2‐(4‐nitrophenyl)ethoxycarbonyl (npeoc) residue, which was also used for aglycon protection.
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Resmini et al. (1993) studied this question.
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