New insight into the mild and regioselective formation of silyl enol ethers, a new way to synthesize β-ketal ketones by a novel variation of the Mukaiyama Aldol reaction, and a number of unprecedented cascade reactions that furnish novel polycyclic, highly oxygenated compounds from simple starting materials are some of the key results from these studies (see scheme). In addition, the first detailed proposed mechanism for the biosynthesis of trichodimerol is presented. Trichodimerol is important because of its potential medical use against septic shock.
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Nicolaou et al. (1999) studied this question.