Key result
Three-dimensional morphometric mapping of rat tibialis anterior muscles revealed significant spatial variations in fiber type organization, including differences between right and left limbs.
Provides a detailed high-resolution, 3-dimensional map of rat tibialis anterior muscle fiber morphometrics to aid in understanding its structure and function.
Should not change clinical practice; leaves open whether rat limb asymmetries translate to human muscle disorders.
INTRODUCTION: Quantitative descriptions of fiber type organization in hind limb muscles are incomplete or rare. METHODS: Fiber morphometrics for both rat tibialis anterior (TA) muscles were measured in 3 dimensions. RESULTS: Slow oxidative fiber area and perimeter varied in all zones. Fast oxidative glycolytic fibers (FOG) were predominant in the mediolateral and posterior zones, and fast glycolytic fibers (FG) predominated in the anterior zone. The mean area of FOG and succinate dehydrogenase intermediate fibers was lowest in the anterior zone. Mean area of FG was highest in the proximal and distal parts of the muscle. The area and perimeter of fast fibers differed significantly between the right and left limbs in the medial zone. In the middle and lateral zones, they differed at the proximal and distal parts. CONCLUSIONS: This detailed analysis in a high resolution, 3-dimensional map provides an essential tool for understanding the structure and function of TA muscles.
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Kalpidis et al. (2013) studied this question. Three-dimensional morphometric mapping was evaluated on Fiber morphometrics for both rat tibialis anterior (TA) muscles. Three-dimensional morphometric mapping of rat tibialis anterior muscles revealed significant spatial variations in fiber type organization, including differences between right and left limbs.
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