Key result
Myoadenylate deaminase deficiency was associated with a greater decline in maximal force-generating capacity compared to controls after 5 minutes of exercise (70.6% vs 87.2% of baseline; P=0.002).
Why the study?
Does myoadenylate deaminase deficiency reduce the capacity for repetitive submaximal muscle contraction compared to sedentary controls?
Population
16 Dutch subjects, comprising 8 subjects with a primary deficiency of myoadenylate deaminase and 8 sedentary…
Comparison
20 min of repetitive voluntary isometric… vs Sedentary control subjects performing the same…
Design
Case-control
Follow-up
20 minutes
Authors
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May contribute to early fatigue in affected patients; leaves open whether this alters clinical management or outcomes.
Case-Control (n=16)
Does myoadenylate deaminase deficiency reduce the capacity for repetitive submaximal muscle contraction compared to sedentary controls?
Absolute Event Rate: 70.6% vs 87.2%
p-value: p=0.002
Myoadenylate deaminase deficiency is associated with a significantly decreased capacity for repetitive submaximal isometric muscle contractions, leading to early muscle fatigue in most affected subjects.
Ruiter et al. (2002) conducted a case-control in Myoadenylate deaminase (MAD) deficiency (n=16). Myoadenylate deaminase (MAD) deficiency vs. Sedentary control subjects was evaluated on Maximal force-generating capacity (MFGC) after 5 min of exercise (% of baseline) (p=0.002). Myoadenylate deaminase deficiency was associated with a greater decline in maximal force-generating capacity compared to controls after 5 minutes of exercise (70.6% vs 87.2% of baseline; P=0.002).
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