Reference CD curves (measured in methylcyclohexane) of a homologous series of 1 ,2-polyols up to pentols derivatized as anthroates at 1-OH and p-methoxycinnamates at the remaining hydroxyl groups show a systematic trend that greatly simplifies assignments of relative and absolute configurations. The same trend also holds for the corresponding 1-aminopolyols, but not for 2-aminopolvols.
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Zhou et al. (1993) studied this question.
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