The Treatment of Pneumonia With Bacitracin

Article1 May 1951THE TREATMENT OF PNEUMONIA WITH BACITRACINEDWARD H. REISNER JR., M.D., FREDERICK N. BAILEY, M.D., EMANUEL APPELBAUM, M.D., F.A.C.P.EDWARD H. REISNER JR., M.D.Search for more papers by this author, FREDERICK N. BAILEY, M.D.Search for more papers by this author, EMANUEL APPELBAUM, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1945, Johnson, Anker and Meleney1reported the discovery of an antibiotic which they called bacitracin, produced by the Tracey I strain ofB. subtilis. It had a bactericidal spectrum roughly comparable to that of penicillin,2and was well tolerated by laboratory animals3, 4when applied locally or injected systemically. In 1947, Meleney and Johnson2reported the first 100 cases of surgical infections treated locally with bacitracin, with results at least comparable to those obtainable with penicillin. Since then the local use of bacitracin has been successful in the treatment of infections of the skin5and eye, and bacitracin has...Bibliography1. JohnsonAnkerMeleney BAHFL: Bacitracin: a new antibiotic produced by a member of the B. subtilis group, Science 102: 376-377 (Oct. 12) 1945. CrossrefMedlineGoogle Scholar2. MeleneyJohnson FLBA: Bacitracin therapy. The first hundred cases of surgical infections treated locally with the antibiotic, J. A. M. A. 133: 675-680 (March 8) 1947. CrossrefMedlineGoogle Scholar3. ScudiAntopol JVW: Some pharmacological characteristics of bacitracin, Proc. Soc. Exper. Biol. and Med. 66: 558-561, 1947. CrossrefMedlineGoogle Scholar4. ScudiCoretAntopol JVIAW: Some pharmacological characteristics of bacitracin. III. Chronic toxicity studies of commercial bacitracin in the dog and monkey, Proc. Soc. Exper. Biol. and Med. 66: 558-561, 1947. CrossrefMedlineGoogle Scholar5. MillerSlatkinJohnson JLMABA: Local use of bacitracin, J. Invest. Dermat. 10: 179-188, 1948. CrossrefMedlineGoogle Scholar6. MeleneyLongacreAltemeierReisnerPulaskiZintel FLABWAEHEJHA: The efficacy and the safety of the intramuscular administration of bacitracin in various types of surgical and certain medical infections, Surg., Gynec. and Obst. 89: 657-683 (Dec.) 1949. MedlineGoogle Scholar7. ScudiCliftKreuger JVMERA: Some pharmacological characteristics of bacitracin. II. Absorption and excretion of bacitracin in the dog, Proc. Soc. Exper. Biol. and Med. 65: 9-13, 1947. CrossrefMedlineGoogle Scholar8. EagleNewmanGreifBurkholderGoodman HEVRLMSC: The blood levels and renal clearance in rabbits and man of an antibiotic derived from B. subtilis (bacitracin), J. Clin. Investigation 26: 919-928, 1947. CrossrefGoogle Scholar9. ReisnerJohnson EHBA: Unpublished observations. Google Scholar10. Pulaski E: Personal communication. Google Scholar11. FarringtonHull-SmithBunnMcDermott RFHPAW: Streptomycin toxicity—reactions to highly purified drug on long continued administration to human subjects, J. A. M. A. 134: 679 (June 21) 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 1, 1949.From the Fourth Medical Division (New York University), Bellevue Hospital, Dr. Charles H. Nammack, Director.This study was supported by a grant from the United States Public Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHAPPENN is a novel tool for hemolytic activity prediction for therapeutic peptides which employs neural networksCHEMOTHERAPY: THE LABORATORY ASSESSMENT OF NEW DRUGSANTIBIOTICS ISOLATED FROM THE GENUS BACILLUS (BACILLACEAE)Die PneumonienTHE TREATMENT OF BACTERIAL PNEUMONIA WITH ERYTHROMYCIN: A CONTROLLED CLINICAL STUDY*COUNT D. GIBSON JR., M.D., HARRY NUSHAN, M.D., DAN N. ANDERSON, M.D. 1 May 1951Volume 34, Issue 5Page: 1232-1242KeywordsAntibioticsMedical servicesPenicillinPneumoniaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1951 PDF downloadLoading ...