Summary DK/Lm is a new inbred mouse strain with over 20 generations of brother–sister mating. The genotype of the DK/Lm mouse at the black-brown locus isb/band heterozygosity at the agouti locus (Ay/a) is maintained. DK/Lm-Ay/amice become sable in phenotype at the first moult, whereas C57BL/6J-Ay/amice do not. The sable phenotype is defined as that of a mouse whose basic colour is yellow (phaeomelanic) but whose dorsal aspect is more or less darkened by the presence of nonyellow (eumelanic) pigment. At about 6 months of age the DK/Lm mouse gradually reverts to yellow in phenotype. Mice of the two strains are compared. Observations are discussed and related to hypotheses regarding gene action at theaandeloci. The new strain is a useful experimental model for study of the relationship between gene action at the agouti locus and the important pleiotropic effects influenced by this locus.
No takes yet. Share an insight, caveat, or question.
Lamoreux et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: