Key result
DSE scar response predicts all-cause death and MACE in obese African American patients.
Why the study?
Does Dobutamine Stress Echocardiography predict all cause death and major adverse cardiac events in obese African American patients?
Cohort (n=555)
Does Dobutamine Stress Echocardiography predict all cause death and major adverse cardiac events in obese African American patients?
Dobutamine stress echocardiography retains prognostic utility in obese African American patients, with the presence of scar predicting all-cause mortality and MACE.
May inform risk stratification in obese African American patients; hypothesis-generating and requires prospective validation.
Background: The predictive value of Dobutamine Stress Echocardiography (DSE) in the obese African American patient population is not well known. Methods: We conducted a retrospective study of 555 African American patients between 1/1/2001-12/31/2001. DSE responses were classified into normal, ischemia, scar, or scar +/? ischemia. End-points utilized were all cause death (ACD) and major adverse cardiac events (MACE). Results: There were a total of 409 obese patients and 146 non-obese patients. By multi-variate analysis only the scar group in the obese population predicted ACD (p = 0.003) and combined MACE (p = 0.014). Kaplan Meir analysis demonstrated that only the scar group was associated with decrease in freedom from all cause death (p < 0.001) and combined MACE (p < 0.001). Conclusion: DSE retains its prognostic power in the obese African American population and scar has important impli-cations for MACE.
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Khan et al. (2012) conducted a cohort in Obesity (n=555). Dobutamine Stress Echocardiography (DSE) scar response vs. Non-scar DSE responses (normal, ischemia) was evaluated on All cause death (ACD) and major adverse cardiac events (MACE) (p=0.003 for ACD; 0.014 for MACE). A scar response on Dobutamine Stress Echocardiography in obese African American patients predicted all-cause death (p=0.003) and major adverse cardiac events (p=0.014).
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