Key result
Adolescents with diabetes mellitus had significantly higher aortic stiffness in females and lower foot post-ischaemic hyperaemia compared to healthy controls (p<0.05).
Case-Control (n=40)
p-value: p=<0.05
Adolescents with diabetes exhibit early signs of vascular dysfunction, including increased aortic stiffness in females and reduced foot microvascular reactivity.
Indicates early vascular dysfunction in diabetic adolescents; hypothesis-generating for long-term cardiovascular risk prediction.
To evaluate vascular function in diabetic subjects, we studied both the stiffness of the abdominal aorta and the foot microvascular reactivity in 22 diabetic adolescents and 18 controls. The aortic stiffness was significantly higher in diabetic females, but not in males, as compared to age- and gender-matched controls (p < 0.05). Foot post-ischaemic hyperaemia was lower in diabetic subjects than in controls (p < 0.05), while postural vasoconstriction did not differ between the groups. The microvascular reactivity did not correlate with the duration of diabetes, but seemed to be influenced by the insulin regimen. The degree of aortic stiffness and the microvascular reactivity of the foot were not significantly interrelated. Loss of aortic elasticity might be a long-term effect of diabetes, whereas microvascular reactivity seems to reflect the current influence of the metabolic state and insulin treatment.
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Hu et al. (1997) conducted a case-control in Diabetes mellitus (n=40). Diabetes mellitus vs. Age- and gender-matched controls was evaluated on Aortic stiffness and foot post-ischaemic hyperaemia (p=<0.05). Adolescents with diabetes mellitus had significantly higher aortic stiffness in females and lower foot post-ischaemic hyperaemia compared to healthy controls (p<0.05).
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