Key result
Recurrent depression in RA linked to less mindfulness, more pain rumination, and greater fear of progression.
Why the study?
Depressive disorders are common in rheumatoid arthritis and frequently recurrent, prompting examination of differences in trait-mindfulness, pain rumination, and fear of progression according to history of recurrent depression.
Cross-Sectional (n=271)
In patients with rheumatoid arthritis, a history of recurrent depression is associated with increased fear of progression, even when excluding those with currently elevated depressive symptoms.
Supports assessing fear of progression in RA with recurrent depression history; hypothesis-generating for mindfulness interventions.
Depressive disorders are common in rheumatoid arthritis (RA; up to 42%) and are frequently recurrent. We examined differences in trait-mindfulness, pain rumination, and fear of progression (FoP) for people with RA with and without a history of recurrent depression. We recruited 271 people with RA who completed a structured interview for depressive disorders, which identified 152 people who had experienced two or more episodes of depression. We found that a history of recurrent depression was associated with significantly less trait-mindfulness (Cohen’s d = 0.43), more pain rumination (Cohen’s d = 0.42) and increased FoP (Cohen’s d = 0.56). However, when those with elevated depressive symptoms were excluded, differences remained between those with and without recurrent depression only for FoP (Cohen’s d = 0.42). However, both trait-mindfulness and FoP (but not pain rumination) were associated with unique variance in depressive symptoms controlling for a range of covariates.
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Boyse et al. (2026) conducted a cross-sectional in Rheumatoid arthritis (n=271). History of recurrent depression vs. No history of recurrent depression was evaluated on Fear of progression (FoP) (Cohen's d = 0.56). A history of recurrent depression in rheumatoid arthritis was associated with less trait-mindfulness (d=0.43), more pain rumination (d=0.42), and increased fear of progression (d=0.56).
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