Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer

A T ~~N of the.rela tionship be-A tween the clinical am1 tissue culture response to chemotherapeutic.agents on human cancer was undertaken.T h e purpose of the study was t o detcrmine i l a positive correlation csistcd.It was considered possible that if such a re1;itioiiship existed it might be o f value in:(1) the screening of new cancer chemotherapeutic agents for use in the treatment of cancer in man; and (2) the selection of a proper agetit lor the treatment or a giben patient with neoplastic disease.Prelimiiiaiy reports of this 31 i i d y havc previously been 111 order to determine the clinical antl tissue ~u l t u r e responses of chemotherapeutic agents on Iuunan cancer, a biops) specimen oE each patient's tuirior was taken for pathological and tissue culture study.T h e individual tumor was giown ill tissue cultuie aiitl tested against the same chemotherapeutic agent as that used in the treatment of-the paticnt from whom the tumor was obtained.T h e cancer chemotherapeutic agents employed in this study were: ( 1) the metabolic ;I ti tagon istq-amcthopterin (Methotrexate) and 5-fluorouracil (5-Ft7); (2) the cytotoxic agentstrie th~letictliiophosphoramide (TSPA), chloranihucil (Leukeran or CB 1348), antl phenylalanine nitrogen niustard (Melphalan or CB 3025) ; ii nd (3) the ant ibio lics-D hydro E-73, 1 : ~ --1:roiii the Departniciit of Surgery, Ncrv York Medical Ccnter, 550 First Ave.. Scw York 16, N.Y.