High-yielding endo-selective intramolecular nitrone-alkene cycloaddition (INAC) reactions of hept-6-enoses controlled by a trans-acetonide to give bridged bicyclo[4.2.1]isoxazolidines exclusively are realized for the first time. The cycloadducts were readily transformed into calystegine, tropane, and hydroxylated aminocycloheptane frameworks. [reaction: see text].
No takes yet. Share an insight, caveat, or question.
Shing et al. (2006) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: