Key result
Elective SAVR in patients >75 linked to ~8-point quality of life improvement at 2 years.
Why the study?
Does elective isolated surgical aortic valve replacement improve quality of life in patients older than 75 years?
Observational (n=138)
No
Does elective isolated surgical aortic valve replacement improve quality of life in patients older than 75 years?
Absolute Event Rate: 67.4% vs 59.1%
p-value: p=0.024
SAVR appears to improve quality of life in patients over 75, but results may be biased by higher mortality and loss to follow-up among sedentary patients with lower baseline quality of life.
BACKGROUND: To evaluate the results of elective isolated surgical aortic valve replacement (SAVR) on quality of life (QoL) in patients > 75 years. METHODS: 138 patients operated between January 2008 and December 2011 were included. The EuroQOL questionnaire (EQ-5D, EQ-VAS) was completed preoperatively, and 1- and 2-years postoperatively. The logistic EuroSCORE was used for risk stratification, the Corpus Christi Heart project criteria to assess physical activity. RESULTS: Mean age was 79.5 ± 2.8 years, mean risk 9.7 ± 5.4, hospital mortality 2.8 %. For 115 patients (83.3 %) the preoperative QoL information was complete. Fifty patients were classified as sedentary. In the first postoperative year 13 patients died, mostly sedentary patients (p = 0.046) with a low EQ-5D (p = 0.017). There was no QoL information on 32 survivors, mostly sedentary patients (p = 0.001). The 70 patients with QoL information showed an increased QoL (NS). Two years postoperatively, 16 patients died, significantly more sedentary patients (p = 0.015) with a low EQ-5D (p = 0.006). For 42 survivors, there was no QoL information; these were mostly sedentary patients (p = 0.021). The 57 patients with 2-year QoL information had an increased EQ-5D (NS) and EQ-VAS (p = 0.024). CONCLUSIONS: QoL increases after SAVR. However, the patients lost to follow-up were mostly sedentary or had a low preoperative QoL, which can lead to biased results.
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Laar et al. (2015) conducted an observational in Aortic valve stenosis (n=138). Elective isolated surgical aortic valve replacement (SAVR) vs. Preoperative baseline was evaluated on Quality of life (EQ-VAS) at 2 years postoperatively (p=0.024). Elective isolated surgical aortic valve replacement in patients older than 75 years significantly increased self-reported quality of life (EQ-VAS) from 59.1 to 67.4 at 2 years.
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